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Fibrosis-4 (FIB-4) Index Calculator

Noninvasive estimate of liver scarring in HCV and HBV patients, to assess need for biopsy
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FIB-4 Index Calculator

Enter your patient's laboratory values to calculate the FIB-4 score for liver fibrosis assessment.

Use with caution in patients <35 or >65 years old, as the score has been shown to be less reliable in these patients
Normal range: 8-48 U/L
Normal range: 7-55 U/L
Normal range: 150-450 ×10³/µL

FIB-4 Index Score

0.00
Low Risk

Interpretation will appear here

📄 PDF Report Preview

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Clinical Interpretation

How to Use This Liver Fibrosis Calculator

The FIB-4 index is a simple, non-invasive scoring system that helps assess liver fibrosis risk in patients with chronic liver diseases.

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Step 1: Input Data

Enter accurate laboratory values for age, AST, ALT, and platelet count from recent blood tests.

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Step 2: Calculate Score

Our algorithm computes the FIB-4 index using the validated formula: (Age × AST) / (Platelets × √ALT)

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Step 3: Interpret Results

Receive detailed risk categorization with clinical recommendations based on established cutoffs.

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Step 4: Save & Share

Download professional PDF reports for medical records or consultation with healthcare providers.

Advanced Features

  • Professional PDF Reports: Generate comprehensive medical reports with all calculations and interpretations
  • Accurate FIB-4 Calculation: Uses the validated formula for reliable liver fibrosis assessment
  • Graphical Visualization: Visual representation of risk categories for easy interpretation
  • Detailed Medical Advice: Clinical recommendations based on calculated scores
  • Mobile Responsive: Accessible on smartphones, tablets, and desktop computers
  • No Registration Required: Free tool with no sign-up needed for immediate use

Frequently Asked Questions

What is included in the PDF report? +
How accurate is the FIB-4 calculator? +
Can I share the PDF report with my doctor? +
Is my data stored when I generate a PDF? +
What do the different score ranges mean? +
Can this tool replace a liver biopsy? +

Medical References & Sources

Primary FIB-4 Validation Studies

  • Sterling RK, et al. Development of a simple noninvasive index to predict significant fibrosis in patients with HIV/HCV coinfection. Hepatology. 2006;43(6):1317-1325. doi:10.1002/hep.21178
  • Vallet-Pichard A, et al. FIB-4: an inexpensive and accurate marker of fibrosis in HCV infection. Hepatology. 2007;46(1):32-36. doi:10.1002/hep.21669
  • Shah AG, et al. Comparison of noninvasive markers of fibrosis in patients with nonalcoholic fatty liver disease. Clin Gastroenterol Hepatol. 2009;7(10):1104-1112. doi:10.1016/j.cgh.2009.05.033

Clinical Guidelines & Recommendations

  • European Association for the Study of the Liver (EASL). EASL Clinical Practice Guidelines: Management of hepatocellular carcinoma. J Hepatol. 2018;69(1):182-236. doi:10.1016/j.jhep.2018.03.019
  • American Association for the Study of Liver Diseases (AASLD). Diagnosis and Management of Nonalcoholic Fatty Liver Disease. Hepatology. 2018;67(1):328-357. doi:10.1002/hep.29367
  • World Health Organization (WHO). Guidelines for the care and treatment of persons diagnosed with chronic hepatitis C virus infection. 2018. WHO Guidelines

Cut-off Values & Validation

  • McPherson S, et al. Simple non-invasive fibrosis scoring systems can reliably exclude advanced fibrosis in patients with non-alcoholic fatty liver disease. Gut. 2010;59(9):1265-1269. doi:10.1136/gut.2010.216077
  • Angulo P, et al. The NAFLD fibrosis score: A noninvasive system that identifies liver fibrosis in patients with NAFLD. Hepatology. 2007;45(4):846-854. doi:10.1002/hep.21496
  • Kim BK, et al. Risk assessment of hepatocellular carcinoma in patients with chronic hepatitis B using FIB-4 index. Liver Int. 2016;36(6):858-865. doi:10.1111/liv.13044

Additional Resources

Online Medical Calculators & Tools:

Professional Organizations:

Disclaimer: This tool is based on established medical literature and clinical guidelines. The references provided are for informational purposes only. Healthcare providers should use clinical judgment in conjunction with this tool. Always refer to the most current clinical guidelines and consult with specialists when managing complex liver disease cases.

Last Literature Review: Studies and guidelines published up to 2023 have been considered in the development of this calculator.

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